Context Thyroid nodules are very common, and 7% to 15% of them are diagnosed as thyroid
cancer. However, the inherited genetic risk factors for thyroid nodules and their associations …

Thyroid hormones are key regulators of cellular growth, development, and metabolism, and
thyroid disorders are a common cause of ill health in the community. Circulating …

Objectives Although an association between type 1 diabetes (T1D) and hypothyroidism has
been found in multiple observational studies, whether T1D plays a causal role in the …

Context: Recently six DNA variants, two of which (M55V and 001Msp) are present in nuclear
factor-κB inhibitors SUMO-4 and MAP3K7IP2 and four of which (fcrl3_3, fcrl3_4, fcrl3_5, and …

Thyroid dysfunction is an important public health problem, which affects 10% of the general
population and increases the risk of cardiovascular morbidity and mortality. Many aspects of …

Background Congenital hypothyroidism from thyroid dysgenesis (CHTD) is predominantly a
sporadic disease characterized by defects in the differentiation, migration or growth of …

The aim of this study was to investigate the associations of DNA methyltransferases
(DNMTs) polymorphisms with susceptibility to autoimmune thyroid diseases (AITDs) and to …

Context Previous genome-wide association studies have shown that single-nucleotide
polymorphism (SNP) rs2439302 in chromosome 8p12 is significantly associated with …

Background Human blood metabolites have demonstrated close associations with thyroid
disorders in observational studies. However, it's essential to determine whether these …

Background Thyroid hormone (TH) action takes place intracellularly; therefore, transport
across the plasma membrane by specific TH transporters, such as MCT8, MCT10 and …