Human brain organogenesis: Toward a cellular understanding of development and disease
The construction of the human nervous system is a distinctly complex although highly
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …
3D brain organoids: studying brain development and disease outside the embryo
S Velasco, B Paulsen, P Arlotta - Annual review of neuroscience, 2020 - annualreviews.org
Scientists have been fascinated by the human brain for centuries, yet knowledge of the
cellular and molecular events that build the human brain during embryogenesis and of how …
cellular and molecular events that build the human brain during embryogenesis and of how …
Brain organoids for the study of human neurobiology at the interface of in vitro and in vivo
I Chiaradia, MA Lancaster - Nature Neuroscience, 2020 - nature.com
Brain development is an extraordinarily complex process achieved through the spatially and
temporally regulated release of key patterning factors. In vitro neurodevelopmental models …
temporally regulated release of key patterning factors. In vitro neurodevelopmental models …
Cell diversity in the human cerebral cortex: from the embryo to brain organoids
P Arlotta, SP Paşca - Current opinion in neurobiology, 2019 - Elsevier
Highlights•Current understanding of human brain development comes mainly from animal
models.•Directly observing and manipulating the developing primate brain is …
models.•Directly observing and manipulating the developing primate brain is …
Brain organoids and the study of neurodevelopment
CA Trujillo, AR Muotri - Trends in molecular medicine, 2018 - cell.com
Brain organoids are 3D self-assembled structures composed of hundreds of thousands to
millions of cells that resemble the cellular organization and transcriptional and epigenetic …
millions of cells that resemble the cellular organization and transcriptional and epigenetic …
Brain organoids as tools for modeling human neurodevelopmental disorders
Brain organoids recapitulate in vitro the specific stages of in vivo human brain development,
thus offering an innovative tool by which to model human neurodevelopmental disease. We …
thus offering an innovative tool by which to model human neurodevelopmental disease. We …
Brain organoids: human neurodevelopment in a dish
S Benito-Kwiecinski… - Cold Spring Harbor …, 2020 - cshperspectives.cshlp.org
The human brain is often described as the most complex organ in our body. Because of the
limited accessibility of living brain tissue, human-specific features of neurodevelopment and …
limited accessibility of living brain tissue, human-specific features of neurodevelopment and …
Brain organoids: advances, applications and challenges
Brain organoids are self-assembled three-dimensional aggregates generated from
pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic …
pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic …
Application of human brain organoids—opportunities and challenges in modeling human brain development and neurodevelopmental diseases
S Kim, MY Chang - International journal of molecular sciences, 2023 - mdpi.com
Brain organoids are three-dimensional (3D) structures derived from human pluripotent stem
cells (hPSCs) that reflect early brain organization. These organoids contain different cell …
cells (hPSCs) that reflect early brain organization. These organoids contain different cell …
Brain organoids: an ensemble of bioassays to investigate human neurodevelopment and disease
J Sidhaye, JA Knoblich - Cell Death & Differentiation, 2021 - nature.com
Understanding etiology of human neurological and psychiatric diseases is challenging.
Genomic changes, protracted development, and histological features unique to human brain …
Genomic changes, protracted development, and histological features unique to human brain …