Polycystin 1, the product of the PKD1 gene, is mutated in autosomal dominant polycystic
kidney disease, a disease characterized by renal cyst formation and progressive renal …

The PKD1 protein, polycystin-1, is a large transmembrane protein of uncertain function and
topology. To study the putative functions of polycystin-1, conditionally immortalized kidney …

Polycystin-1 (PC-1) is a large plasma-membrane receptor encoded by the PKD1 gene
mutated in autosomal dominant polycystic kidney disease (ADPKD). Although the disease is …

Mutations of either PKD1 or PKD2 cause autosomal dominant polycystic kidney disease, a
syndrome characterized by extensive formation of renal cysts and progressive renal failure …

The 14 kb mRNA of the polycystic kidney disease gene PKD1 encodes a novel large (~ 460
kDa) protein, polycystin-1, of unknown function that is responsible for autosomal dominant …

Autosomal dominant polycystic kidney disease (ADPKD) is a common human genetic
disease characterized by cyst formation in kidney tubules and other ductular epithelia. Cells …

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the formation of
multiple fluid-filled cysts that expand over time and destroy the renal architecture. Loss or …

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the formation of
fluid‐filled cysts in both kidneys, in addition to a variety of extra‐renal manifestations. The …

Mutations in PKD1 cause autosomal dominant polycystic kidney disease (ADPKD), a
common genetic disease in which cysts form from kidney tubules. The predicted product of …

Mutations in the PKD1 gene are responsible for> 85% of autosomal dominant polycystic
kidney disease (ADPKD). The protein product of PKD1, polycystin-1, is a large, modular …