The proper expression of Hox genes is necessary for the accurate patterning of the body
plan. The elucidation of the developmental genetic basis of transcriptional regulation of Hox …

Vertebrate Hox genes regulate many aspects of embryonic body plan development and
patterning. In particular, Hox genes have been shown to regulate regional patterning of the …

It has long been known that Hox genes are central players in patterning the vertebrate axial
skeleton. Extensive genetic studies in the mouse have revealed that the combinatorial …

To characterize cis-acting regulatory elements of the murine homeobox gene, Hox-2. 2,
transgenic mouse lines were generated that contained the LacZ reporter gene under the …

Hox genes control morphogenesis along the antero-posterior axis. The skeleton of
vertebrates offers an exemplar readout of their activity: Hox genes control the morphology of …

Differential Hox gene expression between vertebrate species has been implicated in the
divergence of axial morphology. To examine this relationship, we have compared …

The ancestral role of the Hox gene family is specifying morphogenetic differences along the
main body axis. In vertebrates, HoxD genes were also co-opted along with the emergence of …

Genetic analyses have revealed the essential role of the murine Hoxa5 gene for the correct
specification of the cervical and upper thoracic region of the skeleton, and for the normal …

Hox genes are crucial for body axis specification during embryonic development. Hoxa11
plays a role in anteroposterior patterning of the axial skeleton, development of the urogenital …

Recent studies provide compelling new evidence that Hox gene effects depend on fine-
structure spatial and temporal information. Further, in a specific cell type, only one or a few …