We present a method allowing determination of resting cerebral oxygen metabolism
(CMRO2) from MRI and end-tidal O2 measurements acquired during a pair of respiratory …

Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI)
is most commonly used in a semi-quantitative manner to infer changes in brain activity …

Calibrated MRI techniques use the changes in cerebral blood flow (CBF) and blood
oxygenation level‐dependent (BOLD) signal evoked by a respiratory manipulation to …

MRI may be used to measure fractional changes in cerebral oxygen metabolism via a
metabolic model. One step commonly used in this measurement is calibration with image …

Several techniques have been proposed to estimate relative changes in cerebral metabolic
rate of oxygen consumption (CMRO 2) by exploiting combined BOLD fMRI and cerebral …

Measuring the global cerebral metabolic rate of oxygen (CMRO 2) is a valuable tool for
assessing brain vitality and function. Measurement of blood oxygen saturation (HbO 2) and …

New MRI methods for noninvasive imaging of baseline oxygen extraction fraction (OEF) in
the brain show great promise. Quantitative O 2 imaging (QUO2) applies a biophysical model …

Because of the importance of oxidative energetics for cerebral function, extraction of oxygen
consumption (CMRO2) from blood oxygenation level‐dependent (BOLD) signal using multi …

Functional magnetic resonance imaging typically measures signal increases arising from
changes in the transverse relaxation rate over small regions of the brain and associates …

We have recently described an extension of calibrated MRI, which we term QUO2 (for
QUantitative O2 imaging), providing absolute quantification of resting oxidative metabolism …