The mouse is an established model organism for the study of genomic imprinting. Mice with
genetic material originating from only one parent (eg, mice with uniparental chromosomal …

Genomic imprinting refers to a specialized form of epigenetic gene regulation whereby the
expression of a given allele is dictated by parental origin. Defining the extent and distribution …

Genomic imprinting restricts gene expression to a paternal or maternal allele. To date,∼ 90
imprinted transcripts have been identified in mouse, of which the majority were detected …

In the mid-1980s, elegant studies on mouse embryos revealed that both parental genomes
are required for normal development leading to the discovery of genomic imprinting …

We have developed an integrated database that is specialized for the study of imprinted
disease genes. The database contains novel candidate imprinted genes identified by the …

Genomic imprinting in mammals was discovered over 30 years ago through elegant
embryological and genetic experiments in mice. Imprinted genes show a monoallelic and …

Approximately 100 mouse genes undergo genomic imprinting, whereby one of the two
parental alleles is epigenetically silenced. Imprinted genes influence processes including …

Genomic imprinting is an epigenetic process that restricts gene expression to either the
maternally or paternally inherited allele,. Many theories have been proposed to explain its …

Genomic imprinting results in parental-specific gene expression. Imprinted genes are
involved in the etiology of rare syndromes and have been associated with common diseases …

Genomic imprinting arises from allele-specific epigenetic modifications that are established
during gametogenesis and that are maintained throughout somatic development. These …