Carcinogenesis is thought to occur through a combination of mutational and epimutational
events that disrupt key pathways regulating cellular growth and division. The DNA …

The epigenetic landscape of cancer includes both focal hypermethylation and broader
hypomethylation in a genome-wide manner. By means of a comprehensive genomic …

The model describing that aberrant CpG island (CGI) methylation leads to repression of
tumour suppressor genes in cancers has been influential, but it remains unclear how such …

CpG islands are associated with at least half of all cellular genes and are normally
methylation-free. Dense methylation of cytosine residues within islands causes strong and …

Background Methylation of high-density CpG regions known as CpG Islands (CGIs) has
been widely described as a mechanism associated with gene expression regulation …

Global loss of DNA methylation and CpG island (CGI) hypermethylation are key epigenomic
aberrations in cancer. Global loss manifests itself in partially methylated domains (PMDs) …

Cancer epigenetics is rapidly moving into a translational phase, and knowledge on how
aberrant DNA methylation is induced is becoming important. Aging, chronic inflammation …

We have come a long way since the first reports of the existence of aberrant DNA
methylation in human cancer. Hypermethylation of CpG islands located in the promoter …

Epigenetic silencing associated with aberrant methylation of promoter region CpG islands is
one mechanism leading to loss of tumor suppressor function in human cancer. Profiling of …

Epigenetic modifications such as aberrant DNA methylation reshape the gene expression
repertoire in cancer. Here, we used a clinically relevant hepatocellular carcinoma (HCC) …