During postnatal development, the DNA methyltransferase DNMT3A deposits high levels of
non-CG cytosine methylation in neurons. This methylation is critical for transcriptional …

Background Down syndrome (DS) is characterized by a genome-wide profile of differential
DNA methylation that is skewed towards hypermethylation in most tissues, including brain …

The de novo DNA methyltransferase DNMT3B functions in establishing DNA methylation
patterns during development. DNMT3B missense mutations cause immunodeficiency …

DNA methylation at proximal promoters facilitates lineage restriction by silencing cell type–
specific genes. However, euchromatic DNA methylation frequently occurs in regions outside …

Abstract DNA methyltransferase 3a (DNMT3A) plays a crucial role during mammalian
development. Two isoforms of DNMT3A are differentially expressed from stem cells to …

Abstract Methylated non-CpGs (mCpH; H means A, C, and T) have emerged as key
epigenetic marks in mammalian embryonic stem cells (ESCs) and neurons, regulating cell …

DNA methyltransferases (DNMTs) deposit DNA methylation, which regulates gene
expression and is essential for mammalian development. Histone post-translational …

DNA methylation at CG sites is important for gene regulation and embryonic development. In
mouse oocytes, de novo CG methylation requires preceding transcription-coupled histone …

Previously, we reported global hypermethylation in DS might be attributed to the
overexpression of HSA21 gene DNMT3L, which can enhance DNMT3A and DNMT3B …

Dnmt1 and Dnmt3a are important DNA methyltransferases that are expressed in postmitotic
neurons, but their function in the CNS is unclear. We generated conditional mutant mice that …