Targeted inhibition of gut microbial trimethylamine N-oxide production reduces renal tubulointerstitial fibrosis and functional impairment in a murine model of chronic …
Objective: Gut microbial metabolism of dietary choline, a nutrient abundant in a Western diet,
produces trimethylamine (TMA) and the atherothrombosis-and fibrosis-promoting metabolite …
produces trimethylamine (TMA) and the atherothrombosis-and fibrosis-promoting metabolite …
Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice
W Zhang, A Miikeda, J Zuckerman, X Jia… - Scientific Reports, 2021 - nature.com
Patients with chronic kidney disease (CKD) have elevated circulating levels of
trimethylamine N-oxide (TMAO), a metabolite derived from gut microbes and associated with …
trimethylamine N-oxide (TMAO), a metabolite derived from gut microbes and associated with …
Gut Microbiota-Dependent Trimethylamine N-Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney …
Rationale: Trimethylamine-N-oxide (TMAO), a gut microbial-dependent metabolite of dietary
choline, phosphatidylcholine (lecithin), and l-carnitine, is elevated in chronic kidney …
choline, phosphatidylcholine (lecithin), and l-carnitine, is elevated in chronic kidney …
[HTML][HTML] The role of trimethylamine N-oxide as a mediator of cardiovascular complications in chronic kidney disease
JAP Tomlinson, DC Wheeler - Kidney international, 2017 - Elsevier
Patients with chronic kidney disease (CKD) have an enhanced risk of cardiovascular (CV)
morbidity and mortality when compared with age-and gender-matched individuals with …
morbidity and mortality when compared with age-and gender-matched individuals with …
Increased circulating trimethylamine N-oxide contributes to endothelial dysfunction in a rat model of chronic kidney disease
T Li, C Gua, B Wu, Y Chen - Biochemical and biophysical research …, 2018 - Elsevier
Chronic kidney disease (CKD) is strongly associated with increased cardiovascular risk.
Impaired endothelial function, a key initiating step in the pathogenesis of cardiovascular …
Impaired endothelial function, a key initiating step in the pathogenesis of cardiovascular …
Impaired renal function and dysbiosis of gut microbiota contribute to increased trimethylamine-N-oxide in chronic kidney disease patients
KY Xu, GH Xia, JQ Lu, MX Chen, X Zhen, S Wang… - Scientific Reports, 2017 - nature.com
Chronic kidney disease (CKD) patients have an increased risk of cardiovascular diseases
(CVDs). The present study aimed to investigate the gut microbiota and blood trimethylamine …
(CVDs). The present study aimed to investigate the gut microbiota and blood trimethylamine …
[HTML][HTML] Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II–induced hypertension
S Jiang, Y Shui, Y Cui, C Tang, X Wang, X Qiu, W Hu… - Redox biology, 2021 - Elsevier
Gut microbiota produce Trimethylamine N-oxide (TMAO) by metabolizing dietary
phosphatidylcholine, choline, l-carnitine and betaine. TMAO is implicated in the …
phosphatidylcholine, choline, l-carnitine and betaine. TMAO is implicated in the …
Gut microbial metabolite TMAO contributes to renal dysfunction in a mouse model of diet-induced obesity
G Sun, Z Yin, N Liu, X Bian, R Yu, X Su, B Zhang… - Biochemical and …, 2017 - Elsevier
Emerging evidence shows that obesity induces renal injury and is an independent risk factor
for the development of chronic kidney disease (CKD), even without diabetes or …
for the development of chronic kidney disease (CKD), even without diabetes or …
Elevation of trimethylamine-N-oxide in chronic kidney disease: contribution of decreased glomerular filtration rate
CC Pelletier, M Croyal, L Ene, A Aguesse… - Toxins, 2019 - mdpi.com
Gut microbiota-dependent Trimethylamine-N-oxide (TMAO) has been reported to be strongly
linked to renal function and to increased cardiovascular events in the general population …
linked to renal function and to increased cardiovascular events in the general population …
Metabolomics analysis of human plasma reveals decreased production of trimethylamine N‐oxide retards the progression of chronic kidney disease
DY Hu, MY Wu, GQ Chen, BQ Deng… - British Journal of …, 2022 - Wiley Online Library
Background and Purpose Chronic kidney disease (CKD) is a global public health problem
and one of the leading causes of all‐cause mortality. However, the pathogenic mechanisms …
and one of the leading causes of all‐cause mortality. However, the pathogenic mechanisms …
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