The effect of an aerobic exercise bout 24 h prior to each doxorubicin treatment for breast cancer on markers of cardiotoxicity and treatment symptoms: a RCT

AA Kirkham, ND Eves, RE Shave, KA Bland… - Breast cancer research …, 2018 - Springer
Purpose In rodents, a single exercise bout performed 24 h prior to a single doxorubicin
treatment provides cardio-protection. This study investigated whether performing this …

Protective effects of acute exercise prior to doxorubicin on cardiac function of breast cancer patients: A proof-of-concept RCT

AA Kirkham, RE Shave, KA Bland, JM Bovard… - International Journal of …, 2017 - Elsevier
Background Preclinical studies have reported that a single treadmill session performed 24 h
prior to doxorubicin provides cardio-protection. We aimed to characterize the acute change …

The effects of exercise on cardiovascular outcomes before, during, and after treatment for breast cancer

KM Sturgeon, B Ky, JR Libonati, KH Schmitz - Breast cancer research and …, 2014 - Springer
Asymptomatic cardiotoxicity following breast cancer treatment is a significant issue for many
patients, as these patients typically face an increased risk of cardiovascular disease (CVD) …

Trastuzumab and doxorubicin-related cardiotoxicity and the cardioprotective role of exercise

KY Wonders, BS Reigle - Integrative cancer therapies, 2009 - journals.sagepub.com
Women diagnosed with breast cancer typically undergo a multimodal approach to treating
their disease. The treatments used often result in sequelae such as fatigue, hair loss …

Exercise training affects hemodynamics not cardiac function during anthracycline-based chemotherapy

AA Kirkham, SA Virani, KA Bland, DC McKenzie… - Breast Cancer Research …, 2020 - Springer
Introduction Preclinical data demonstrate the potential for exercise training to protect against
anthracycline-related cardiotoxicity, but this remains to be shown in humans. Purpose To …

Exercise as a diagnostic and therapeutic tool for the prevention of cardiovascular dysfunction in breast cancer patients

EJ Howden, A Bigaran, R Beaudry… - European journal of …, 2019 - academic.oup.com
Background Anthracycline chemotherapy may be associated with decreased cardiac
function and functional capacity measured as the peak oxygen uptake during exercise (V· O …

Modulation of anthracycline-induced cardiotoxicity by aerobic exercise in breast cancer: current evidence and underlying mechanisms

JM Scott, A Khakoo, JR Mackey, MJ Haykowsky… - Circulation, 2011 - Am Heart Assoc
Anthracycline-containing chemotherapy (eg, doxorubi-cin) is well known to cause dose-
dependent, progressive cardiac damage clinically manifest as decreased left ventricular …

Utility of 3-dimensional echocardiography, global longitudinal strain, and exercise stress echocardiography to detect cardiac dysfunction in breast cancer patients …

MG Khouri, WE Hornsby, N Risum… - Breast cancer research …, 2014 - Springer
Conventional resting left ventricular ejection fraction (LVEF) assessments have limitations
for detecting doxorubicin (DOX)-related cardiac dysfunction. Novel resting …

Attenuating treatment-related cardiotoxicity in women recently diagnosed with breast cancer via a tailored therapeutic exercise program: protocol of the ATOPE trial

P Postigo-Martin, R Penafiel-Burkhardt… - Physical …, 2021 - academic.oup.com
Objective Therapeutic exercise is already used to ameliorate some of the side effects of
cancer treatment. Recent studies examined its preventive potential regarding treatment …

Effects of exercise training on cardiac toxicity markers in women with breast cancer undergoing chemotherapy with anthracyclines: a randomized controlled trial

P Antunes, A Joaquim, F Sampaio… - European Journal of …, 2023 - academic.oup.com
Aims Exercise training has been suggested to prevent anthracycline-related cardiac
dysfunction, but clinicalbased evidence is scarce. We investigated the effects of a …