Transgenerational impaired spermatogenesis with sperm H19 and Gtl2 hypomethylation induced by the endocrine disruptor p, p'-DDE
Y Song, L Yang - Toxicology Letters, 2018 - Elsevier
The hypothesis of fetal origins unraveled that environmental exposures in early life could
alter epigenetic modifications in the male germ-line, increasing the susceptibility to adult …
alter epigenetic modifications in the male germ-line, increasing the susceptibility to adult …
Transgenerational impaired male fertility with an Igf2 epigenetic defect in the rat are induced by the endocrine disruptor p,p′-DDE
Y Song, N Wu, S Wang, M Gao, P Song… - Human …, 2014 - academic.oup.com
Since the 1990s, various studies (Carlsen et al., 1992; Swan et al., 2000; Rolland et al.,
2013) have reported that young males in developed or industrialized countries have …
2013) have reported that young males in developed or industrialized countries have …
Transgenerational pancreatic impairment with Igf2/H19 epigenetic alteration induced by p, p'-DDE exposure in early life
Y Song, L Yang - Toxicology letters, 2017 - Elsevier
The hypothesis of fetal origins indicates that exposures in early development could induce
epigenetic modifications in the male germ-line, affecting the susceptibility of adult-onset …
epigenetic modifications in the male germ-line, affecting the susceptibility of adult-onset …
Paternal developmental toxicant exposure is associated with epigenetic modulation of sperm and placental Pgr and Igf2 in a mouse model
T Ding, S Mokshagundam, PF Rinaudo… - Biology of …, 2018 - academic.oup.com
Preterm birth (PTB), parturition prior to 37 weeks' gestation, is the leading cause of neonatal
mortality. The causes of spontaneous PTB are poorly understood; however, recent studies …
mortality. The causes of spontaneous PTB are poorly understood; however, recent studies …
Prenatal exposure to DEHP affects spermatogenesis and sperm DNA methylation in a strain-dependent manner
Di-(2-ethylhexyl) phtalate (DEHP) is a plasticizer with endocrine disrupting properties found
ubiquitously in the environment and altering reproduction in rodents. Here we investigated …
ubiquitously in the environment and altering reproduction in rodents. Here we investigated …
Germline-dependent transmission of male reproductive traits induced by an endocrine disruptor, di-2-ethylhexyl phthalate, in future generations
In males, defective reproductive traits induced by an exposure to an endocrine disruptor are
transmitted to future generations via epigenetic modification of the germ cells. Interestingly …
transmitted to future generations via epigenetic modification of the germ cells. Interestingly …
The mechanism of environmental endocrine disruptors (DEHP) induces epigenetic transgenerational inheritance of cryptorchidism
J Chen, S Wu, S Wen, L Shen, J Peng, C Yan, X Cao… - PloS one, 2015 - journals.plos.org
Discussion on the role of DEHP in the critical period of gonadal development in pregnant
rats (F0), studied the evolution of F1-F4 generation of inter-generational inheritance of …
rats (F0), studied the evolution of F1-F4 generation of inter-generational inheritance of …
Pesticide and insect repellent mixture (permethrin and DEET) induces epigenetic transgenerational inheritance of disease and sperm epimutations
M Manikkam, R Tracey, C Guerrero-Bosagna… - Reproductive …, 2012 - Elsevier
Environmental compounds are known to promote epigenetic transgenerational inheritance
of disease. The current study was designed to determine if a “pesticide mixture”(pesticide …
of disease. The current study was designed to determine if a “pesticide mixture”(pesticide …
Pubertal exposure to di-(2-ethylhexyl)-phthalate inhibits G9a-mediated histone methylation during spermatogenesis in mice
C Liu, P Qian, L Yang, L Zhang, C Chen, M He… - Archives of …, 2016 - Springer
The increasing incidence of male reproductive impairments has been associated with di-(2-
ethylhexyl)-phthalate (DEHP) exposure. However, mechanisms involved are lacking. We …
ethylhexyl)-phthalate (DEHP) exposure. However, mechanisms involved are lacking. We …
Testicular dysgenesis syndrome and long-lasting epigenetic silencing of mouse sperm genes involved in the reproductive system after prenatal exposure to DEHP
The endocrine disruptor bis (2-ethylhexyl) phthalate (DEHP) has been shown to exert
adverse effects on the male animal reproductive system. However, its mode of action is …
adverse effects on the male animal reproductive system. However, its mode of action is …