Icaritin induces ovarian cancer cell apoptosis through activation of p53 and inhibition of Akt/mTOR pathway

L Gao, M Chen, Y Ouyang, R Li, X Zhang, X Gao, S Lin… - Life sciences, 2018 - Elsevier
Aims Ovarian cancer (OC) has the highest mortality rate of all gynecological cancers.
Currently, the first-line OC treatment consists of cytoreductive surgery and platinum-based …

1′-Acetoxychavicol acetate suppresses angiogenesis-mediated human prostate tumor growth by targeting VEGF-mediated Src-FAK-Rho GTPase-signaling pathway

X Pang, L Zhang, L Lai, J Chen, Y Wu, Z Yi… - …, 2011 - academic.oup.com
Cancer therapeutic agents that are safe, effective and affordable are urgently needed. We
describe that 1′-acetoxychavicol acetate (ACA), a component of Siamese ginger (Languas …

Amentoflavone suppresses tumor growth in ovarian cancer by modulating Skp2

H Liu, Q Yue, S He - Life sciences, 2017 - Elsevier
Aim Ovarian cancer is one of most common malignancies in women and is associated with
high reoccurrence rate and poor prognosis. This study is designed to investigate the anti …

[PDF][PDF] Icariin inhibits the growth of human cervical cancer cells by inducing apoptosis and autophagy by targeting mTOR/PI3K/AKT signalling pathway

S Huang, T Xie, W Liu - J buon, 2019 - jbuon.com
Purpose: Cervical cancer causes significant morbidity and mortality among women
worldwide. The currently available treatment options are not efficacious and also create …

Ethyl cinnamate suppresses tumor growth through anti-angiogenesis by attenuating VEGFR2 signal pathway in colorectal cancer

S Wang, J Yang, X Kuang, H Li, H Du, Y Wu… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Kaempferia galanga Linn. is an aromatic
medicinal herb with extensively applied in India, China, Malaysia and other South Asia …

Apigenin, a dietary flavonoid, inhibits proliferation of human bladder cancer T-24 cells via blocking cell cycle progression and inducing apoptosis

MD Shi, CK Shiao, YC Lee, YW Shih - Cancer cell international, 2015 - Springer
Background Apigenin is a nontoxic dietary flavonoid, and it may have chemopreventive and
therapeutic potential as an anti-inflammatory, antioxidant, and anti-cancer agent. However …

Novel angiogenesis inhibitory activity in cinnamon extract blocks VEGFR2 kinase and downstream signaling

J Lu, K Zhang, S Nam, RA Anderson, R Jove… - …, 2010 - academic.oup.com
As a critical factor in the induction of angiogenesis, vascular endothelial growth factor
(VEGF) has become an attractive target for anti-angiogenesis treatment. However, the side …

Acacetin inhibited non-small-cell lung cancer (NSCLC) cell growth via upregulating miR-34a in vitro and in vivo

J Li, X Zhong, Y Zhao, J Shen, Z Xiao, C Pilapong - Scientific Reports, 2024 - nature.com
Acacetin, one of the flavonoid compounds, is a natural product found in various plants,
including Silver birch, and Damiana. Previous studies showed that acacetin has anti-cancer …

Protoapigenone, a novel flavonoid, inhibits ovarian cancer cell growth in vitro and in vivo

HL Chang, JH Su, YT Yeh, YC Lee, HM Chen, YC Wu… - Cancer letters, 2008 - Elsevier
Flavonoids are polyphenolic compounds and capable of inhibiting the growth of human
cancer cells. Protoapigenone, a novel flavonoid, was isolated from the whole plant …

Marine algal carotenoids inhibit angiogenesis by down-regulating FGF-2-mediated intracellular signals in vascular endothelial cells

P Ganesan, K Matsubara, T Sugawara… - Molecular and cellular …, 2013 - Springer
Discovery of natural compounds as effective angiogenesis inhibitors has become an
important approach in the prevention of cancer. We previously demonstrated the anti …