Aims: Glucuronoxylomannan (GXM) is the major polysaccharide component of
Cryptococcus neoformans. We evaluated in this study whether GXM fractions of different …

The mechanisms by which macromolecules are transported through the cell wall of fungi are
not known. A central question in the biology of Cryptococcus neoformans, the causative …

Cryptococcus neoformans is a facultative intracellular pathogen. The most distinctive feature
of C. neoformans is a polysaccharide capsule that enlarges depending on environmental …

The aim of this investigation was to study the effect of polysaccharide capsule on the gene
expression in dendritic cells (DC) during their interaction with Cryptococcus neoformans. To …

Polysaccharides are complex carbohydrates composed of more than a dozen
monosaccharide units connected by glycosidic linkages [1]. Unlike proteins and nucleic …

Two isolates of Cryptococcus neoformans were previously described as being highly
divergent in their level of capsule synthesis in vivo and in their virulence for mice. The highly …

The capsule of the human pathogenic fungus Cryptococcus neoformans presents the
immune system with a formidable problem for phagocytosis. Capsule‐mediated activation of …

Cryptococcus neoformans is an opportunistic pathogen responsible for serious disease in
humans. Critical for virulence of this fungus is an elaborate polysaccharide capsule, which …

Pathogenic species of Cryptococcus kill approximately 200,000 people each year. The most
important virulence mechanism of C. neoformans and C. gattii, the causative agents of …

The major virulence factor of the pathogenic fungi Cryptococcus neoformans and C. gattii is
the capsule. Glucuronoxylomannan (GXM), the major component of the capsule, is a high …