Background: The optimal dose of tranexamic acid (TA) is still an issue. The authors
compared two doses of TA during cardiac surgery in a multicenter, double-blinded …

Purpose This randomized controlled clinical trial compared three doses of tranexamic acid
(TA) in primary cardiac surgery in terms of blood loss and transfusion requirements. Methods …

Background Tranexamic acid (TA) reduces blood loss and blood transfusion during heart
surgery with cardiopulmonary bypass (CPB). TA dosing has been empiric because only …

Background It is unclear whether high-dose regimens of tranexamic acid in cardiac surgery
(total dose, 80 to 100 mg/kg) confer a clinical advantage over low-dose regimens (total dose …

Objective (s): The authors have developed an alternative dosing schedule for tranexamic
acid that incorporates the effects of renal function on tranexamic acid concentrations. The …

Background The efficacy of tranexamic acid (TXA) to reduce perioperative blood loss and
allogeneic blood transfusion in cardiac surgeries has been proved in previous studies, but …

Aim Prophylactic administration of tranexamic acid decreases bleeding and transfusions
after cardiac procedures but it is still unclear what the best dose and the most appropriate …

Purpose The objective of this study was to assess the effect of tranexamic acid (TA), a
synthetic antifibrinolytic, on blood loss and the need for transfusion of blood products …

Objective Tranexamic acid (TA), a synthetic antifibrinolytic drug, has been shown to reduce
postoperative bleeding and the need for allogeneic blood transfusion in cardiac surgery …

Background Many different doses and administration schemes have been proposed for the
use of the antifibrinolytic drug tranexamic acid during cardiac surgery. This study evaluated …