[PDF][PDF] Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A–deficient mice
CB Rountree, S Senadheera, JM Mato… - …, 2008 - Wiley Online Library
Methionine adenosyltransferase (MAT) is an essential enzyme that catalyzes the
biosynthesis of S‐adenosylmethionine. Hepatic MAT activity falls in chronic liver diseases …
biosynthesis of S‐adenosylmethionine. Hepatic MAT activity falls in chronic liver diseases …
[PDF][PDF] CD133+ liver cancer stem cells from methionine adenosyl transferase 1A–deficient mice demonstrate resistance to transforming growth factor (TGF)‐β …
W Ding, M Mouzaki, H You, JC Laird, J Mato… - …, 2009 - Wiley Online Library
Methionine adenosyltransferase (MAT) is an essential enzyme required for S‐
adenosylmethionine biosynthesis. Hepatic MAT activity falls during chronic liver injury, and …
adenosylmethionine biosynthesis. Hepatic MAT activity falls during chronic liver injury, and …
S-adenosylmethionine synthesis: molecular mechanisms and clinical implications
JM Mato, L Alvarez, P Ortiz, MA Pajares - Pharmacology & therapeutics, 1997 - Elsevier
Methionine adenosyltransferase (MAT) is an ubiquitous enzyme that catalyzes the synthesis
of S-adenosylmethionine from methionine and ATP. In mammals, there are two genes …
of S-adenosylmethionine from methionine and ATP. In mammals, there are two genes …
[PDF][PDF] Excess S‐adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis
M Martínez‐Uña, M Varela‐Rey, A Cano… - …, 2013 - Wiley Online Library
Methionine adenosyltransferase 1A (MAT1A) and glycine N‐methyltransferase (GNMT) are
the primary genes involved in hepatic S‐adenosylmethionine (SAMe) synthesis and …
the primary genes involved in hepatic S‐adenosylmethionine (SAMe) synthesis and …
Functional proteomics of nonalcoholic steatohepatitis: Mitochondrial proteins as targets of S-adenosylmethionine
E Santamaría, MA Avila, MU Latasa… - Proceedings of the …, 2003 - National Acad Sciences
Recent work shows that S-adenosylmethionine (AdoMet) helps maintain normal liver
function as chronic hepatic deficiency results in spontaneous development of steatohepatitis …
function as chronic hepatic deficiency results in spontaneous development of steatohepatitis …
S-Adenosylmethionine synthesis is regulated by selective N6-adenosine methylation and mRNA degradation involving METTL16 and YTHDC1
H Shima, M Matsumoto, Y Ishigami, M Ebina, A Muto… - Cell reports, 2017 - cell.com
S-adenosylmethionine (SAM) is an important metabolite as a methyl-group donor in DNA
and histone methylation, tuning regulation of gene expression. Appropriate intracellular …
and histone methylation, tuning regulation of gene expression. Appropriate intracellular …
HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis
M Vázquez–Chantada, D Fernández–Ramos… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Hepatic de-differentiation, liver development, and malignant
transformation are processes in which the levels of hepatic S-adenosylmethionine are tightly …
transformation are processes in which the levels of hepatic S-adenosylmethionine are tightly …
Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits
MAT (methionine adenosyltransferase) utilizes l-methionine and ATP to form SAM (S-
adenosylmethionine), the principal methyl donor in biological methylation. Mammals encode …
adenosylmethionine), the principal methyl donor in biological methylation. Mammals encode …
S-adenosylmethionine stabilizes cystathionine β-synthase and modulates redox capacity
A Prudova, Z Bauman, A Braun… - Proceedings of the …, 2006 - National Acad Sciences
The transsulfuration pathway converts homocysteine to cysteine and represents the
metabolic link between antioxidant and methylation metabolism. The first and committing …
metabolic link between antioxidant and methylation metabolism. The first and committing …
S-adenosylmethionine: From the discovery of its inhibition of tumorigenesis to its use as a therapeutic agent
RM Pascale, MM Simile, DF Calvisi, CF Feo, F Feo - Cells, 2022 - mdpi.com
Alterations of methionine cycle in steatohepatitis, cirrhosis, and hepatocellular carcinoma
induce MAT1A decrease and MAT2A increase expressions with the consequent decrease of …
induce MAT1A decrease and MAT2A increase expressions with the consequent decrease of …