While DNA methylation plays a role in T-helper (Th) cell maturation, its potential
dysregulation in the non-atopic Th1-polarized systemic inflammation observed in obesity …

Background Childhood asthma is a result of a complex interaction of genetic and
environmental components causing epigenetic and immune dysregulation, airway …

Epigenome-wide studies of methylation in children support a role for epigenetic
mechanisms in asthma; however, studies in adults are rare and few have examined non …

Epigenetic changes including DNA methylation caused by environmental exposures may
contribute to the heterogeneous inflammatory response in asthma. Here we investigate …

Background Asthma is highly heterogeneous, and severity evaluation is key to asthma
management. DNA methylation (DNAm) contributes to asthma pathogenesis. This study …

Background Epigenetic marks are heritable, influenced by the environment, direct the
maturation of T lymphocytes, and in mice enhance the development of allergic airway …

Background Nasal (airway) epithelial methylation profiles have been associated with
asthma, but the effects of such profiles on expression of distant cis-genes are largely …

Background Epigenetic mechanisms, including methylation, can contribute to childhood
asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease …

Background DNA methylation profiles associated with childhood asthma might provide
novel insights into disease pathogenesis. We did an epigenome-wide association study to …

Background Epigenetic mechanisms could alter the airway epithelial barrier and ultimately
lead to atopic diseases such as asthma. We aimed to identify DNA methylation profiles that …