Background The influence of genetic variation on complex diseases is potentially mediated
through a range of highly dynamic epigenetic processes exhibiting temporal variation during …

Multiple recent studies highlight that genetic variants can have strong impacts on a
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …

Characterizing the complex relationship between genetic, epigenetic, and transcriptomic
variation has the potential to increase understanding about the mechanisms underpinning …

The methylome is subject to genetic and environmental effects. Their impact may depend on
sex and age, resulting in sex-and age-related physiological variation and disease …

DNA methylation plays an important role in the regulation of transcription. Genetic control of
DNA methylation is a potential candidate for explaining the many identified SNP …

Background The functional impact of genetic variation has been extensively surveyed,
revealing that genetic changes correlated to phenotypes lie mostly in non-coding genomic …

Variation in DNA methylation is being increasingly associated with health and disease
outcomes. Although DNA methylation is hypothesized to be a mechanism by which both …

Studies of DNA methylation (DNAm) in solid human tissues are relatively scarce; tissue-
specific characterization of DNAm is needed to understand its role in gene regulation and its …

DNA methylation (DNAm) is known to play a pivotal role in childhood health and
development, but a comprehensive characterization of genome-wide DNAm trajectories …

Background Despite the important role DNA methylation plays in transcriptional regulation,
the transgenerational inheritance of DNA methylation is not well understood. The genetic …