BACKGROUND DNA methylation patterns differ among children and adults and play an
unambiguous role in several disease processes, particularly cancers. The origin of these …

Background Changes in DNA methylation patterns with age frequently have been observed
and implicated in the normal aging process and its associated increasing risk of disease …

Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …

One plausible mechanism for the environment to alter cancer susceptibility is through DNA
methylation. Alterations in DNA methylation can lead to genomic instability and altered gene …

Background Among children, sex-specific differences in disease prevalence, age of onset,
and susceptibility have been observed in health conditions including asthma, immune …

DNA methylation of CpGs located in two types of repetitive elements—LINE1 (L1) and Alu—
is used to assess “global” changes in DNA methylation in studies of human disease and …

Prenatal development and early childhood are critical periods for establishing the tissue-
specific epigenome, and may have a profound impact on health and disease in later life …

Background DNA methylation is an important epigenetic mark that can potentially link early
life exposures to adverse health outcomes later in life. Host factors like sex and age strongly …

Cytosine-5 methylation within CpG dinucleotides is a potentially important mechanism of
epigenetic influence on human traits and disease. In addition to influences of age and …

Background There is growing evidence that DNA methylation alterations contribute to
carcinogenesis. While cancer tissue exhibits widespread DNA methylation changes, the …