Mechanical stress from blood flow has a significant effect on endothelial physiology, with a
key role in initiating vasoregulatory signals. Disturbances in blood flow, such as in regions of …

Cardiovascular disease (CVD) is a serious health challenge, causing more deaths
worldwide than cancer. The vascular endothelium, which forms the inner lining of blood …

Significance: Forces are important in the cardiovascular system, acting as regulators of
vascular physiology and pathology. Residing at the blood vessel interface, cells (endothelial …

Mechanical forces influence different cell types in our bodies. Among the earliest forces
experienced in mammals is blood movement in the vascular system. Blood flow starts at the …

Vascular endothelial cells (ECs) play significant roles in regulating circulatory functions.
Mechanical stimuli, including the stretch and shear stress resulting from circulatory pressure …

Forces that are associated with blood flow are major determinants of vascular
morphogenesis and physiology. Blood flow is crucial for blood vessel development during …

Vascular endothelial cells (ECs) form a semiselective barrier for macromolecules and cell
elements regulated by dynamic interactions between cytoskeletal elements and cell …

The endothelial surface is a highly flexible signaling hub which is able to sense the
hemodynamic forces of the streaming blood. The subsequent mechanosignaling is basically …

This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Blood vessels are lined by a single layer of endothelial cells that provide a barrier between
circulating plasma and the underlying tissue. Permeability of endothelial cells is tightly …