Zebrafish (Danio rerio) larvae have been suggested as vertebrate model to complement or
even replace mammals for rapidly assessing behavioral effects of psychoactive drugs. Yet …

The acute responses to cocaine and its withdrawal contribute to cocaine dependence and
potentiate relapse, with gender being one of the genetic factors affecting the outcome. Here …

As part of the development of a rapid in vivo screen for prioritization of toxic chemicals, we
have begun to characterize the locomotor activity of zebrafish (Danio rerio) larvae by …

Continued usage of cocaine is determined by genetic, conditioned and homeostatic factors,
while it is reinforced by drug-induced reward and the emotionally negative state of drug …

Zebrafish (Danio rerio) have been used as a model organism to explore the genetic basis for
responsiveness to addictive drugs like cocaine. However, very little is known about how the …

The number of new psychoactive substances (NPS) increases rapidly, harming society and
fuelling the need for alternative testing strategies. These should allow the ever-increasing …

Lidocaine is a voltage-gated Na+ channel blocker, commonly used as a fast-acting local and
general anesthetic. Lidocaine also has central action, affecting behavior both clinically and …

Mounting evidence implicates the zebrafish (Danio rerio) as a promising model species for
reward and addiction research. Modeling drug abuse-related behavior in both adult and …

The use of psychotropic drugs in clinical and translational brain research continues to grow,
and the need for novel experimental models and screens is becoming widely recognized …

Drug abuse and brain disorders related to drug comsumption are public health problems
with harmful individual and social consequences. The identification of therapeutic targets …