Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the role of innate and adaptive immune components

AM van der Sar, HP Spaink, A Zakrzewska, W Bitter… - Molecular …, 2009 - Elsevier
Pathogenic mycobacteria have the ability to survive within macrophages and persist inside
granulomas. The complex host–pathogen interactions that determine the outcome of a …

Transcriptome profiling of adult zebrafish at the late stage of chronic tuberculosis due to Mycobacterium marinum infection

AH Meijer, FJ Verbeek, E Salas-Vidal… - Molecular …, 2005 - Elsevier
The Mycobacterium marinum–zebrafish infection model was used in this study for analysis
of a host transcriptome response to mycobacterium infection at the organismal level. RNA …

Deep sequencing of the innate immune transcriptomic response of zebrafish embryos to Salmonella infection

A Ordas, Z Hegedus, CV Henkel… - Fish & shellfish …, 2011 - Elsevier
Salmonella enterica serovar Typhimurium (S. typhimurium) bacteria cause an inflammatory
and lethal infection in zebrafish embryos. To characterize the embryonic innate host …

Transcriptomic approaches in the zebrafish model for tuberculosis—insights into host-and pathogen-specific determinants of the innate immune response

EL Benard, J Rougeot, PI Racz, HP Spaink… - Advances in …, 2016 - Elsevier
Mycobacterium marinum infection in zebrafish has become a well-established model of
tuberculosis. Both embryonic and adult zebrafish infection studies have contributed to our …

Deep sequencing of the zebrafish transcriptome response to mycobacterium infection

Z Hegedűs, A Zakrzewska, VC Ágoston, A Ordas… - Molecular …, 2009 - Elsevier
Novel high-throughput deep sequencing technology has dramatically changed the way that
the functional complexity of transcriptomes can be studied. Here we report on the first use of …

Insights into early mycobacterial pathogenesis from the zebrafish

R Lesley, L Ramakrishnan - Current opinion in microbiology, 2008 - Elsevier
Here we discuss the application of the zebrafish as a relatively new model host for the study
of mycobacterial pathogenesis. Recent advances in our understanding of host …

A fresh look at mycobacterial pathogenicity with the zebrafish host model

M Varela, AH Meijer - Molecular Microbiology, 2022 - Wiley Online Library
The zebrafish has earned its place among animal models to study tuberculosis and other
infections caused by pathogenic mycobacteria. This model host is especially useful to study …

[HTML][HTML] Adequate Th2-type response associates with restricted bacterial growth in latent mycobacterial infection of zebrafish

MM Hammaren, KE Oksanen, HM Nisula… - PLoS …, 2014 - journals.plos.org
Tuberculosis is still a major health problem worldwide. Currently it is not known what kind of
immune responses lead to successful control and clearance of Mycobacterium tuberculosis …

Mycobacterium marinum Infection of Adult Zebrafish Causes Caseating Granulomatous Tuberculosis and Is Moderated by Adaptive Immunity

LE Swaim, LE Connolly, HE Volkman… - Infection and …, 2006 - Am Soc Microbiol
The zebrafish, a genetically tractable model vertebrate, is naturally susceptible to
tuberculosis caused by Mycobacterium marinum, a close genetic relative of the causative …

[HTML][HTML] The case for modeling human infection in zebrafish

MC Gomes, S Mostowy - Trends in microbiology, 2020 - cell.com
Zebrafish (Danio rerio) larvae are widely recognized for studying host–pathogen interactions
in vivo because of their optical transparency, genetic manipulability, and translational …