Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the role of innate and adaptive immune components
Pathogenic mycobacteria have the ability to survive within macrophages and persist inside
granulomas. The complex host–pathogen interactions that determine the outcome of a …
granulomas. The complex host–pathogen interactions that determine the outcome of a …
Transcriptome profiling of adult zebrafish at the late stage of chronic tuberculosis due to Mycobacterium marinum infection
The Mycobacterium marinum–zebrafish infection model was used in this study for analysis
of a host transcriptome response to mycobacterium infection at the organismal level. RNA …
of a host transcriptome response to mycobacterium infection at the organismal level. RNA …
Deep sequencing of the innate immune transcriptomic response of zebrafish embryos to Salmonella infection
A Ordas, Z Hegedus, CV Henkel… - Fish & shellfish …, 2011 - Elsevier
Salmonella enterica serovar Typhimurium (S. typhimurium) bacteria cause an inflammatory
and lethal infection in zebrafish embryos. To characterize the embryonic innate host …
and lethal infection in zebrafish embryos. To characterize the embryonic innate host …
Transcriptomic approaches in the zebrafish model for tuberculosis—insights into host-and pathogen-specific determinants of the innate immune response
Mycobacterium marinum infection in zebrafish has become a well-established model of
tuberculosis. Both embryonic and adult zebrafish infection studies have contributed to our …
tuberculosis. Both embryonic and adult zebrafish infection studies have contributed to our …
Deep sequencing of the zebrafish transcriptome response to mycobacterium infection
Z Hegedűs, A Zakrzewska, VC Ágoston, A Ordas… - Molecular …, 2009 - Elsevier
Novel high-throughput deep sequencing technology has dramatically changed the way that
the functional complexity of transcriptomes can be studied. Here we report on the first use of …
the functional complexity of transcriptomes can be studied. Here we report on the first use of …
Insights into early mycobacterial pathogenesis from the zebrafish
R Lesley, L Ramakrishnan - Current opinion in microbiology, 2008 - Elsevier
Here we discuss the application of the zebrafish as a relatively new model host for the study
of mycobacterial pathogenesis. Recent advances in our understanding of host …
of mycobacterial pathogenesis. Recent advances in our understanding of host …
A fresh look at mycobacterial pathogenicity with the zebrafish host model
The zebrafish has earned its place among animal models to study tuberculosis and other
infections caused by pathogenic mycobacteria. This model host is especially useful to study …
infections caused by pathogenic mycobacteria. This model host is especially useful to study …
[HTML][HTML] Adequate Th2-type response associates with restricted bacterial growth in latent mycobacterial infection of zebrafish
MM Hammaren, KE Oksanen, HM Nisula… - PLoS …, 2014 - journals.plos.org
Tuberculosis is still a major health problem worldwide. Currently it is not known what kind of
immune responses lead to successful control and clearance of Mycobacterium tuberculosis …
immune responses lead to successful control and clearance of Mycobacterium tuberculosis …
Mycobacterium marinum Infection of Adult Zebrafish Causes Caseating Granulomatous Tuberculosis and Is Moderated by Adaptive Immunity
LE Swaim, LE Connolly, HE Volkman… - Infection and …, 2006 - Am Soc Microbiol
The zebrafish, a genetically tractable model vertebrate, is naturally susceptible to
tuberculosis caused by Mycobacterium marinum, a close genetic relative of the causative …
tuberculosis caused by Mycobacterium marinum, a close genetic relative of the causative …
[HTML][HTML] The case for modeling human infection in zebrafish
Zebrafish (Danio rerio) larvae are widely recognized for studying host–pathogen interactions
in vivo because of their optical transparency, genetic manipulability, and translational …
in vivo because of their optical transparency, genetic manipulability, and translational …