DNA methylation is a central epigenetic modification that is established by de novo DNA
methyltransferases. The mechanisms underlying the generation of genomic methylation …

DNA methylation, one of the major epigenetic mechanisms, plays critical roles in regulating
gene expression, genomic stability and cell lineage commitment. The establishment and …

The DNTM3A and DNMT3B de novo DNA methyltransferases (DNMTs) are responsible for
setting genomic DNA methylation patterns, a key layer of epigenetic information. Here, using …

As part of the epigenetic network, DNA methylation is a major regulator of chromatin
structure and function. In mammals, it mainly occurs at palindromic CpG sites, but …

Despite their central importance in mammalian development, the mechanisms that regulate
the DNA methylation machinery and thereby the generation of genomic methylation patterns …

Mammalian DNA methylation patterns are established by two de novo DNA
methyltransferases, DNMT3A and DNMT3B, which exhibit both redundant and distinctive …

DNA methylation maintenance by DNMT1 is an essential process in mammals but molecular
mechanisms connecting DNA methylation patterns and enzyme activity remain elusive …

Inactive DNA methyltransferase (DNMT) 3B splice isoforms are associated with changes in
DNA methylation, yet the mechanisms by which they act remain largely unknown. Using …

DNA methylation plays a critical role in regulating gene expression, genomic stability, and
cell fate commitment. Mammalian DNA methylation, which mostly occurs in the context of …

DNA methyltransferase 1 (DNMT1) is a multidomain protein believed to be involved only in
the passive transmission of genomic methylation patterns via maintenance methylation. The …