Lifelong regular physical activity is associated with reduced risk of type 2 diabetes (T2D),
maintenance of muscle mass and increased metabolic capacity. However, little is known …

Exercise training prevents age‐related decline in muscle function. Targeting epigenetic
aging is a promising actionable mechanism and late‐life exercise mitigates epigenetic aging …

To identify epigenetic patterns, which may predispose to type 2 diabetes (T2D) due to a
family history (FH) of the disease, we analyzed DNA methylation genome-wide in skeletal …

Skeletal muscle tissue demonstrates global hypermethylation with age. However,
methylome changes across the time-course of differentiation in aged human muscle derived …

Human aging is accompanied by a decline in muscle mass and muscle function, which is
commonly referred to as sarcopenia. Sarcopenia is associated with detrimental clinical …

Physical activity is a strong stimulus influencing the overall physiology of the human body.
Exercises lead to biochemical changes in various tissues and exert an impact on gene …

The adaptive response of skeletal muscle to exercise training is tightly controlled and
therefore requires transcriptional regulation. DNA methylation is an epigenetic mechanism …

Transcriptome wide changes in human skeletal muscle after acute (anabolic) and chronic
resistance exercise (RE) induced hypertrophy have been extensively determined in the …

Background Exercise training elicits changes in muscle physiology, epigenomics,
transcriptomics, and proteomics, with males and females exhibiting differing physiological …

A decline in skeletal muscle mass and function with aging is well recognized, but remains
poorly characterized at the molecular level. Here, we report for the first time a genome‐wide …