Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex
LJ Newby, AJ Streets, Y Zhao, PC Harris… - Journal of Biological …, 2002 - ASBMB
The functions of the two proteins defective in autosomal dominant polycystic kidney disease,
polycystin-1 and polycystin-2, have not been fully clarified, but it has been hypothesized that …
polycystin-1 and polycystin-2, have not been fully clarified, but it has been hypothesized that …
Polycystin-1 distribution is modulated by polycystin-2 expression in mammalian cells
DH Grimm, Y Cai, V Chauvet, V Rajendran… - Journal of Biological …, 2003 - ASBMB
Mutations in PKD1 and PKD2, the genes that encode polycystin-1 and polycystin-2
respectively, account for almost all cases of autosomal dominant polycystic kidney disease …
respectively, account for almost all cases of autosomal dominant polycystic kidney disease …
Polycystin: In vitro synthesis, in vivo tissue expression, and subcellular localization identifies a large membrane-associated protein
O Ibraghimov-Beskrovnaya… - Proceedings of the …, 1997 - National Acad Sciences
The primary structure of polycystin predicts a large integral membrane protein with multiple
cell recognition motifs, but its function remains unknown. Insight into polycystin's normal …
cell recognition motifs, but its function remains unknown. Insight into polycystin's normal …
Biochemical characterization of bona fide polycystin-1 in vitro and in vivo
The most common form of autosomal dominant polycystic kidney disease (PKD) results from
mutation of the PKD1 gene on chromosome 16p13. 3. The gene encodes a 14-kb …
mutation of the PKD1 gene on chromosome 16p13. 3. The gene encodes a 14-kb …
Coordinate expression of the autosomal dominant polycystic kidney disease proteins, polycystin-2 and polycystin-1, in normal and cystic tissue
A second gene for autosomal dominant polycystic kidney disease (ADPKD), PKD2, has
been recently identified. Using antisera raised to the human PKD2 protein, polycystin-2, we …
been recently identified. Using antisera raised to the human PKD2 protein, polycystin-2, we …
[HTML][HTML] A polycystin-centric view of cyst formation and disease: the polycystins revisited
ACM Ong, PC Harris - Kidney international, 2015 - Elsevier
It is 20 years since the identification of PKD1, the major gene mutated in autosomal
dominant polycystic kidney disease (ADPKD), followed closely by the cloning of PKD2 …
dominant polycystic kidney disease (ADPKD), followed closely by the cloning of PKD2 …
Autosomal dominant polycystic kidney disease: molecular analysis
Using a positional cloning approach the major autosomal dominant polycystic kidney
disease (ADPKD) gene (PKD1) has been identified on chromosome 16: a disease …
disease (ADPKD) gene (PKD1) has been identified on chromosome 16: a disease …
Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations
Polycystin-1 plays an essential role in renal tubular morphogenesis, and disruption of its
function causes cystogenesis in human autosomal-dominant polycystic kidney disease …
function causes cystogenesis in human autosomal-dominant polycystic kidney disease …
Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene
L Foggensteiner, AP Bevan, R Thomas… - Journal of the …, 2000 - journals.lww.com
Mutations in the PKD1 and PKD2 genes account for 85 and 15% of cases of autosomal
dominant polycystic kidney disease, respectively. Polycystin-2, the product of the PKD2 …
dominant polycystic kidney disease, respectively. Polycystin-2, the product of the PKD2 …
Characterization and cell distribution of polycystin, the product of autosomal dominant polycystic kidney disease gene 1
Background In a majority of cases, autosomal dominant polycystic kidney disease (ADPKD)
is caused by mutations within a putative open reading frame of the PKD1 gene. The …
is caused by mutations within a putative open reading frame of the PKD1 gene. The …