The expression of polycystin-1 in the vascular smooth muscle cells (VSMC) of elastic and
large distributive arteries suggests that some vascular manifestations of autosomal …

Analysis of the C-terminal cytosolic domain of human and mouse polycystin-1 has identified
a number of conserved protein motifs, including a 20-amino-acid heterotrimeric G-protein …

Polycystins-1,-2,-L, and-REJ are the four known members of the polycystin family of proteins.
In this study, we describe a fifth member of the family, polycystin-L2, encoded by PKD2L2 in …

Polycystin-1, the protein defective in a majority of patients with autosomal dominant
polycystic kidney disease, is a ubiquitously expressed multi-span transmembrane protein of …

PKD2 is mutated in 15% of patients with autosomal dominant polycystic kidney disease.
Polycystin-2 (PC2), the PKD2 protein, is a non-selective Ca2+-permeable cation channel …

Autosomal dominant polycystic kidney disease is caused by loss-of-function mutations in the
PKD1 or PKD2 genes encoding respectively polycystin-1 and polycystin-2. Polycystin-2 …

The PKD1 gene accounts for 85% of autosomal dominant polycystic kidney disease
(ADPKD), the most common human genetic disorder. Rats with a germline inactivation of …

Recent developments have helped elucidate the function of the autosomal dominant
polycystic kidney disease proteins, polycystin-1 and polycystin-2, and have revealed the …

PKD1 is the major locus of the common genetic disorder autosomal dominant polycystic
kidney disease (ADPKD). Analysis of the predicted protein sequence of the human PKD1 …

Mutations in the PKD1 gene are responsible for 85% of cases of autosomal dominant
polycystic kidney disease (ADPKD). This gene encodes a large membrane associated …