Polycystins-1,-2,-L, and-REJ are the four known members of the polycystin family of proteins.
In this study, we describe a fifth member of the family, polycystin-L2, encoded by PKD2L2 in …

Polycystin-1 transforms the cAMP growth-responsive phenotype of M-1 cells. Background
Polycystic kidney disease (PKD) is characterized by the abnormal proliferation of tubular …

Mutations in the PKD1 gene are responsible for 85% of cases of autosomal dominant
polycystic kidney disease (ADPKD). This gene encodes a large membrane associated …

Recent evidence has suggested an association between structural and/or functional defects
in the primary apical cilium of vertebrate epithelia and polycystic kidney disease (PKD). In …

The cytoplasmic C-terminal portion of the polycystin-1 polypeptide (PKD1 (1–226)) regulates
several important cell signaling pathways, and its deletion suffices to cause autosomal …

Polycystin-1 (PC1), a 4,303-amino acid integral membrane protein of unknown function,
interacts with polycystin-2 (PC2), a 968-amino acid α-type channel subunit. Mutations in …

Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited
nephropathy responsible for 4%–10% of end-stage renal disease cases. Mutations in the …

Autosomal dominant polycystic kidney disease (ADPKD) is a serious, life-threatening
genetic disease in which extensive epithelial-lined cysts develop in the kidneys and, to a …

New insights into the molecular pathophysiology of polycystic kidney disease. Polycystic
kidney diseases are characterized by the progressive expansion of multiple cystic lesions …

Mutations in the polycystin proteins, PC-1 and PC-2, result in autosomal dominant polycystic
kidney disease (ADPKD) and ultimately renal failure. PC-1 and PC-2 enrich on primary cilia …