Validation of a DNA methylation HPV triage classifier in a screening sample

AT Lorincz, AR Brentnall… - … journal of cancer, 2016 - Wiley Online Library
High‐risk human papillomavirus (hrHPV) DNA tests have excellent sensitivity for detection of
cervical intraepithelial neoplasia 2 or higher (CIN2+). A drawback of hrHPV screening …

HPV33 DNA methylation measurement improves cervical pre-cancer risk estimation of an HPV16, HPV18, HPV31 and\textit {EPB41L3} methylation classifier

AR Brentnall, N Vasiljevic… - Cancer …, 2015 - content.iospress.com
BACKGROUND: Persistent infection% by with high risk human papillomavirus (hrHPV) types
causes cervical cancer but most women who test positive are at very low risk of neoplasia …

[HTML][HTML] Triage of hrHPV-positive women: comparison of two commercial methylation-specific PCR assays

C Dippmann, M Schmitz, K Wunsch, S Schütze… - Clinical …, 2020 - Springer
Aim High-risk human papillomavirus (hrHPV)-based screening is becoming increasingly
important, either by supplementing or replacing the traditional cytology-based cervical Pap …

[HTML][HTML] Utility of gene methylation analysis, cytological examination, and HPV-16/18 genotyping in triage of high-risk human papilloma virus-positive women

Y Tian, NYY Wu, YL Liou, CT Yeh, L Cao, YN Kang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract In 2015, the American Society for Colposcopy and Cervical Pathology and the
Society of Gynecologic Oncology issued interim guidance for the use of a human …

[HTML][HTML] Methylation estimates the risk of precancer in HPV-infected women with discrepant results between cytology and HPV16/18 genotyping

R Hernández-López, AT Lorincz, L Torres-Ibarra… - Clinical …, 2019 - Springer
Background Vigilant management of women with high-risk human papillomavirus (hrHPV) is
necessary in cancer screening programs. To this end, we evaluated the performance of S5 …

DNA methylation markers as a triage test for identification of cervical lesions in a high risk human papillomavirus positive screening cohort

RW van Leeuwen, A Oštrbenk, M Poljak… - … Journal of Cancer, 2019 - Wiley Online Library
Objective triage strategies are required to prevent unnecessary referrals for colposcopy in
population‐based screening programs using primary high‐risk human papillomavirus …

DNA methylation testing with S5 for triage of high‐risk HPV positive women

R Adcock, B Nedjai, AT Lorincz… - … Journal of Cancer, 2022 - Wiley Online Library
Methylation of host and viral genes is promising for triage of women with high‐risk human
papillomavirus infections (hrHPV). Using a population‐based sample of hrHPV positive …

Triage performance and predictive value of the human gene methylation panel among women positive on self‐collected HPV test: results from a prospective cohort …

L Zhang, X Zhao, S Hu, S Chen, S Zhao… - … Journal of Cancer, 2022 - Wiley Online Library
Triaging of women positive for high‐risk human papillomavirus (hrHPV) on self‐collected
samples requires a molecular reflex test to avoid recall for cytology or visual tests. We …

Evaluation of a validated methylation triage signature for human papillomavirus positive women in the HPV FOCAL cervical cancer screening trial

DA Cook, M Krajden, AR Brentnall… - … Journal of Cancer, 2019 - Wiley Online Library
Human papillomavirus (HPV)‐based cervical cancer screening requires triage of HPV
positive women to identify those at risk of cervical intraepithelial neoplasia grade 2 (CIN2) or …

A DNA methylation classifier of cervical precancer based on human papillomavirus and human genes

AR Brentnall, N Vasiljević… - … journal of cancer, 2014 - Wiley Online Library
Testing for high‐risk (hr) types of human papillomavirus (HPV) is highly sensitive as a
screening test of high‐grade cervical intraepithelial neoplastic (CIN2/3) disease, the …