Turning back the clock: regression of abdominal aortic aneurysms via pharmacotherapy

H Aoki, K Yoshimura, M Matsuzaki - Journal of Molecular Medicine, 2007 - Springer
Abdominal aortic aneurysm (AAA) is a common disease that causes progressive expansion
and rupture of the aorta with high mortality. There is a large and unmet need for nonsurgical …

Recent advances in pharmacotherapy development for abdominal aortic aneurysm

K Yoshimura, H Aoki - International Journal of Vascular …, 2012 - Wiley Online Library
Abdominal aortic aneurysm (AAA) is a common disease causing segmental expansion and
rupture of the aorta with a high mortality rate. The lack of nonsurgical treatment represents a …

Identification of c‐Jun N‐terminal kinase as a therapeutic target for abdominal aortic aneurysm

K Yoshimura, H Aoki, Y Ikeda, A Furutani… - Annals of the New …, 2006 - Wiley Online Library
Despite the advances in molecular cell biology, identification of a therapeutic target in a
given disease still poses a significant challenge. Here we report a strategy for identification …

Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase

K Yoshimura, H Aoki, Y Ikeda, K Fujii, N Akiyama… - Nature medicine, 2005 - nature.com
Abdominal aortic aneurysm (AAA) is a common disease among elderly people that, when
surgical treatment is inapplicable, results in progressive expansion and rupture of the aorta …

Cellular signaling in abdominal aortic aneurysm

Z Li, W Kong - Cellular signalling, 2020 - Elsevier
Abdominal aortic aneurysms (AAAs) are highly lethal cardiovascular diseases without
effective medications. However, the molecular and signaling mechanisms remain unclear. A …

Regression of abdominal aortic aneurysm by inhibition of c‐Jun N‐terminal kinase in mice

K Yoshimura, H Aoki, Y Ikeda, A Furutani… - Annals of the New …, 2006 - Wiley Online Library
Abdominal aortic aneurysm (AAA) is a common disease that, when surgical treatment is
inapplicable, results in rupture of the aorta with high mortality. Although nonsurgical …

[HTML][HTML] The mechanism and therapy of aortic aneurysms

J Gao, H Cao, G Hu, Y Wu, Y Xu, H Cui, HS Lu… - Signal transduction and …, 2023 - nature.com
Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …

[HTML][HTML] Aortic aneurysms: current pathogenesis and therapeutic targets

MJ Cho, MR Lee, JG Park - Experimental & Molecular Medicine, 2023 - nature.com
Aortic aneurysm is a chronic disease characterized by localized expansion of the aorta,
including the ascending aorta, arch, descending aorta, and abdominal aorta. Although aortic …

The pathophysiologic basis of abdominal aortic aneurysm progression: a critical appraisal

JHN Lindeman - Expert review of cardiovascular therapy, 2015 - Taylor & Francis
An aneurysm of the abdominal aorta is a common pathology and a major cause of sudden
death in the elderly. Currently, abdominal aortic aneurysms (AAAs) can only be treated by …

[HTML][HTML] Dysregulations of key regulators of angiogenesis and inflammation in abdominal aortic aneurysm

D Zalewski, P Chmiel, P Kołodziej, G Borowski… - International Journal of …, 2023 - mdpi.com
Abdominal aortic aneurysm (AAA) is a chronic vascular disease caused by localized
weakening and broadening of the abdominal aorta. AAA is a clearly underdiagnosed …