To evaluate the significance of alterations in DNA methylation during human
hepatocarcinogenesis, we examined levels of mRNA for DNA methyltransferases and …

Down-regulation of tumor suppressor genes by hypermethylation of 5′-CpGs is one of the
important mechanisms involved in tumor development. DNA (5-cytosine)-methyltransferases …

We evaluated the significance of aberrant DNA methyltransferase expression in human
carcinogenesis by examining 32 colorectal and 34 stomach cancers. Levels of mRNAs …

Aberrant DNA methylation on CpG islands is one of the most consistent epigenetic changes
in human cancers, and the methylation process is catalyzed by DNA methyltransferase …

Aberrant DNA methylation and increased expression of DNA methyltransferases (DNMTs)
are features of tumor cells. To investigate roles for DNMTs during hepatocarcinogenesis, we …

DNA hypomethylation on pericentromeric satellite regions is an early and frequent event
associated with heterochromatin instability during human hepatocarcinogenesis. A DNA …

Hypermethylation of cell cycle regulators and increased DNA methyltransferase 1 (Dnmt1)
mRNA level have been reported in hepatocarcinogenesis. However, the expression of …

Alteration of DNA methylation is one of the most consistent epigenetic changes in human
cancers. DNA methyltransferase (DNMT) 1 is a major enzyme involved in establishing …

Aberrant genome-wide hypomethylation has been thought to be related to tumorigenesis.
However, its mechanism and implications in hepatocellular carcinogenesis remain to be …

Background Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-
related mortality in the world; however, the molecular mechanisms leading to hepatocyte …