Somatic changes in CpG dinucleotide methylation occur quite commonly in human cancer
cell DNA. Relative to DNA from normal human colonic cells, DNA from human colorectal …

There are conflicting reports regarding the association between DNA methyltransferases
(DNMTs) expression and global or gene‐specific DNA methylation in colorectal cancer …

The molecular basis of aberrant hypermethylation of CpG islands observed in a subset of
human colorectal tumors is unknown. One potential mechanism is the up-regulation of DNA …

Alterations of DNA methylation are one of the most consistent epigenetic changes in human
cancers. Human cancers generally show global DNA hypomethylation accompanied by …

To determine the methylation profile of multiple tumor-related genes during multistep
hepatocarcinogenesis, we investigated the methylation status of CpG islands of 9 genes …

We evaluated the significance of aberrant DNA methyltransferase 1 (DNMT1) protein
expression during gastric carcinogenesis. The protein expression of DNMT1, Muc2, human …

To evaluate the significance of alterations in DNA methylation during multistage
carcinogenesis of the pancreas, tissue samples of 13 peripheral pancreatic duct epithelia …

Abstract Purpose: DNA methyltransferase-3B (DNMT3B) plays an important role in de novo
CpG island methylation. Dnmt3b can induce colon tumor in mice with methylation in specific …

Transcriptional silencing of tumor suppressor genes and other cancer-related genes
induced by promoter CpG island hypermethylation is an important epigenetic mechanism of …

Promoter hypermethylation mediated by DNA methyltransferases (DNMTs) is the main
reason for epigenetic inactivation of tumor suppressor genes (TSGs). Previous studies …