DNA methylation is a major determinant in the epigenetic silencing of genes. The
mechanisms underlying the targeting of DNA methylation and the subsequent repression of …

DNA methylation and chromatin modification are two global mechanisms that regulate gene
expression. Recent studies provide insight into the mechanism of transcriptional silencing by …

DNA methylation is associated with the silencing of gene expression. The predominant
mechanism involves the methylation of DNA and the subsequent recruitment of binding …

Cancer is a process driven by the accumulation of abnormalities in gene function. While
many of these changes are genetic, epigenetically mediated changes in gene expression …

The regulation of gene transcription is not simply dependent on the presence or absence of
DNA-binding transcription factors that turn genes on or off, but also involves processes …

Active DNA demethylation plays crucial roles in the regulation of gene expression in both
plants and animals. In Arabidopsis thaliana, active DNA demethylation is initiated by the …

During differentiation and development cells undergo dramatic morphological and functional
changes without any change in the DNA sequence. The underlying changes of gene …

DNA methylation is an epigenetic modification which plays an important role in chromatin
organization and gene expression. DNA methylation can silence genes and repetitive …

The covalent modification of eukaryotic DNA by methylation of the 5′ carbon of cytosine
residues is frequently associated with transcriptional silencing. In mammals, a potential …

Genetic, biochemical and cytological studies on DNA methylation in several eukaryotic
organisms have resulted in leaps of understanding in the past three years. Discoveries of …