Methylation of DNA at position five of the cytosine ring occurs at most CpG dinucleotides in
the mammalian genome and is essential for embryonic viability. With several of the key …

A correlation between DNA methylation and transcriptional silencing has existed for many
years. Recently, substantial progress has been reported in the search for proteins that …

The term epigenetic modification denotes reversible traits of gene expression that do not
include alterations to the DNA sequence. These epigenetic alterations are responsible for …

Background In vertebrates and plants, DNA methylation is one of the major mechanisms
regulating gene expression. Recently, a family of methyl‐CpG‐binding proteins has been …

Epigenetic modifications are heritable changes in gene expression not encoded by the DNA
sequence. In the past decade, great strides have been made in characterizing epigenetic …

DNA methylation has an essential regulatory function in mammalian development, serving
to repress nontranscribed genes stably in differentiated adult somatic cells. Recent data …

Both DNA methylation and histone modification are involved in establishing patterns of gene
repression during development. Certain forms of histone methylation cause local formation …

DNA methylation, chromatin structure, transcription, and cancer have traditionally been
studied as separate phenomena. Recent data provide now direct physical and functional …

DNA methylation has recently moved to centre stage in the aetiology of human
neurodevelopmental syndromes such as the fragile X, ICF and Rett syndromes. These …

DNA methylation alterations are now widely recognized as a contributing factor in human
tumorigenesis. A significant number of tumor suppressor genes are transcriptionally …