Over three decades ago DNA methylation had been suggested to play a role in the
regulation of gene expression. This chapter reviews the development of this field of research …

DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

Gene function in cancer can be disrupted either through genetic alterations, which directly
mutate or delete genes, or epigenetic alterations, which alter the heritable state of gene …

DNA methylation acts in concert with other epigenetic mechanisms to regulate normal gene
expression and facilitate chromatin organization within cells. Aberrant DNA methylation …

Cytosine 5! methylation of CpG dinucleotides within and around genes exerts a major
influence on transcription in many plants and animals (1–3). DNA methylation can be causal …

DNA methylation is an important epigenetic mark involved in diverse biological processes.
In plants, DNA methylation can be established through the RNA-directed DNA methylation …

Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …

Differentiation-related DNA methylation is receiving increasing attention, partly owing to
new, whole-genome analyses. These revealed that cell type-specific differential methylation …

Ever since the discovery of DNA methylation at cytosine residues, the role of this so called
fifth base has been extensively studied and debated. Until recently, the majority of DNA …

Methylation of the cytosine base in DNA, DNA methylation, is an essential epigenetic mark
in mammals that contributes to the regulation of transcription. Several advances have been …