The DNA methylation landscape is dynamically patterned during development and distinct
methylation patterns distinguish healthy from diseased cells. However, whether tissue …

Zebrafish (Danio rerio) is a vertebrate model organism that is widely used for studying a
plethora of biological questions, including developmental processes, effects of external cues …

DNA methylation is a dynamic process through which specific chromatin modifications can
be stably transmitted from parent to daughter cells. A large body of work has suggested that …

Genome-wide DNA methylation mapping uncovers epigenetic changes associated with
animal development, environmental adaptation, and species evolution. To address the lack …

Genomic DNA methylation functions to repress gene expression by interfering with
transcription factor binding and/or recruiting repressive chromatin machinery. Recent data …

Patterns of DNA methylation in animal genomes are known to vary from an apparent
absence of modified bases, via methylation of a minor fraction of the genome, to genome …

Background DNA methylation is an epigenetic mechanism with important regulatory
functions in animals. While the mechanism itself is evolutionarily ancient, the distribution and …

The canonical view of DNA methylation, a pivotal epigenetic regulation mechanism in
eukaryotes, dictates its role as a suppressor of gene activity, particularly within promoter …

DNA methylation is an epigenetic mark associated with transcriptional repression and
essential for proper vertebrate development. Because of its association with human …

Epigenetic mechanisms are an underappreciated and often ignored component of an
organism's response to environmental change and may underlie many types of phenotypic …