Base modifications of cytosine are an important aspect of chromatin biology, as they can
directly regulate gene expression, while DNA repair ensures that those modifications retain …

Active DNA demethylation in mammals involves TET-mediated iterative oxidation of 5-
methylcytosine (5mC)/5-hydroxymethylcytosine (5hmC) and subsequent excision repair of …

The successful establishment and stable maintenance of cell identity are critical for
organismal development and tissue homeostasis. Cell identity is provided by epigenetic …

Pathways that control and modulate DNA methylation patterning in mammalian cells were
poorly understood for a long time, although their importance in establishing and maintaining …

DNA methylation is a major epigenetic mechanism for gene silencing. Whereas
methyltransferases mediate cytosine methylation, it is less clear how unmethylated regions …

Variability and adaptability are necessary for overcoming the challenges of multicellular life.
To address this need, nature has evolved a substantial enzymatic toolbox for altering …

Deaminases have important uses in modification detection and genome editing. However,
the range of applications is limited by the small number of characterized enzymes. To …

The covalent DNA modification of cytosine at position 5 (5-methylcytosine; 5mC) has
emerged as an important epigenetic mark most commonly present in the context of CpG …

Mammalian genomes are methylated on carbon-5 of many cytosines, mostly in CpG
dinucleotides. Methylation patterns are maintained during mitosis via DNMT1, and …

Mammalian DNA methylation is a critical epigenetic mechanism orchestrating gene
expression networks in many biological processes. However, investigation of the functions …