DNA methylation is an essential epigenetic mark whose role in gene regulation and its
dependency on genomic sequence and environment are not fully understood. In this study …

DNA methylation is one of the most extensively studied epigenetic marks. It is involved in
transcriptional gene silencing and plays important roles during mammalian development. Its …

Changes in DNA methylation are involved in development, disease, and the response to
environmental conditions. However, not all regulatory elements are functionally methylation …

DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

Background Uncovering mechanisms of epigenome evolution is an essential step towards
understanding the evolution of different cellular phenotypes. While studies have confirmed …

DNA methylation, especially CpG methylation at promoter regions, has been generally
considered as a potent epigenetic modification that prohibits transcription factor (TF) …

Background Early life is a period of drastic epigenetic remodeling in which the epigenome is
especially sensitive to extrinsic and intrinsic influence. However, the epigenome-wide …

Several studies have proved that DNA methylation affects regulation of gene expression and
development. Epigenome-wide studies have reported variation in methylation patterns …

Background DNA methylation plays an essential role in the regulation of gene expression.
While its presence near the transcription start site of a gene has been associated with …

Background DNA methylation plays an important role in regulating gene expression during
many biological processes. However, the mechanism of DNA-methylation-dependent gene …