The central nervous system (CNS) is the most complex tissue of vertebrates. Recently, the
zebrafish has emerged as a powerful genetic system for studying early development, and …

The accessibility and simplicity of the zebrafish embryo have led to fruitful examinations of
how vertebrate embryos develop, at the cellular level. Recently, several groups have …

Large-scale mutant screens in zebrafish have led to the identification of more than 50 genes
affecting various aspects of neural development and function, including neural induction …

In a large scale mutagenesis screen for embryonic mutants in zebrafish, we have identified
63 mutations in 24 loci affecting the morphogenesis of the zebrafish brain. The expression of …

The first systematic, functional screens to identify the genes involved in vertebrate
embryogenesis have been completed in the zebrafish, Danio rerio. In an extraordinary issue …

Exquisite embryonic lethal mutations have been isolated in hundreds of genes necessary for
zebrafish development. Analysis of this resource promises to enhance our understanding of …

Zebrafish provide a rapid and effective means for assessing gene function in the vertebrate
nervous system. By employing gain-and loss-of-function techniques it is possible to obtain …

In recent years, the zebrafish has become a popular system for studying vertebrate
development. Large scale mutant searches have led to the identification of> 400 genes with …

The zebrafish has been prominently utilized in developmental biology for the past three
decades and numerous genetic tools have been developed for it. Due to the accumulated …

We describe an embryonic lethal mutation in the zebrafish Brachydanio rerio that specifically
affects the viability of most cells in the embryonic central nervous system (CNS). The …