Epigenetic mechanisms, including DNA methylation, histone post-translational
modifications, and chromatin structure regulation, are critical for the interactions between …

Dysregulation of the epigenome drives aberrant transcriptional programmes that promote
cancer onset and progression. Although defective gene regulation often affects oncogenic …

Epigenetic regulation allows heritably modulating gene expression profiles without
modifying the primary sequence of gDNA. Under physiologic conditions, epigenetic patterns …

Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …

Epigenetic silencing of immune-related genes is a striking feature of the cancer genome that
occurs in the process of tumorigenesis. This phenomena impacts antigen processing and …

Cancer cells employ a number of mechanisms to escape immunosurveillance and facilitate
tumour progression. The recent explosion of interest in immunotherapy, especially immune …

Epigenetic mechanisms play vital roles not only in cancer initiation and progression, but also
in the activation, differentiation and effector function (s) of immune cells. In this review, we …

During cancer initiation and progression, the somatic epigenome is broadly reprogrammed.
This reprogramming can be a consequence of several processes, including altered …

The tumor immune microenvironment (TIME), an immunosuppressive niche, plays a pivotal
role in contributing to the development, progression, and immune escape of various types of …

A balance between co-inhibitory and co-stimulatory signals in the tumor microenvironment
(TME) is critical to suppress tumor development and progression, primarily via maintaining …