DNA methylation is involved in key cellular processes, including X‐chromosome
inactivation, imprinting and transcriptional silencing of specific genes and repetitive …

Several recent reports have identified TET1 as the main enzyme modulating DNA
methylation and gene transcription via hydroxylation of 5-methylcytosine. However, little is …

The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene
expression, and DNA methylation abnormalities are often observed in diseases. The ten …

TET1 oxidizes methylated cytosine into 5-hydroxymethylcytosine (5hmC), resulting in
regulation of DNA methylation and gene expression. Full length TET1 (TET1FL) has a CXXC …

Cytosine methylation is the major epigenetic modification of metazoan DNA. Although there
is strong evidence that active DNA demethylation occurs in animal cells, the molecular …

Stem cells are defined as cells that have the ability to perpetuate themselves through self-
renewal and to generate functional mature cells by differentiation. During each stage …

One of the main regulators of gene expression during embryogenesis and stem cell
differentiation is DNA methylation. The recent identification of hydroxymethylcytosine …

Promoter CpG methylation is a fundamental regulatory process of gene expression. TET
proteins are active CpG demethylases converting 5-methylcytosine to 5 …

Cancer genomes are characterized by focal increases in DNA methylation, co-occurring with
widespread hypomethylation. Here, we show that TET loss of function results in a similar …

TET proteins, by converting 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), are
hypothesized, but not directly shown, to protect promoter CpG islands (CGIs) against …