The field of epigenetics has recently moved to the forefront of studies relating to diverse
processes such as transcriptional regulation, chromatin structure, genome integrity, and …

Heritable alterations of DNA that do not affect the base pair sequence itself but nevertheless
regulate the predetermined activity of genes are referred to as epigenetic. Epigenetic …

Epigenetic events, such as aberrant DNA methylation, have been demonstrated to silence
the expression of many genes that suppress malignancy. Since the event is reversible, it is …

Cancer epigenetics is rapidly moving into a translational phase, and knowledge on how
aberrant DNA methylation is induced is becoming important. Aging, chronic inflammation …

Although the first studies using DNA demethylating agents at low doses in hematologic
neoplasia and hemoglobinopathies were initiated more than 20 years ago, development of …

It has become clear over the last few years that DNA methylation is essential for normal
embryonic development and that alterations in DNA methylation are very common in cancer …

DNA methylation and histone modification are epigenetic mechanisms that result in altered
gene expression and cellular phenotype. The exact role of methylation in myelodysplastic …

The spatial arrangement and three-dimensional structure of DNA in the nucleus is controlled
through the interdigitation of DNA binding proteins such as histones and their modifiers, the …

Increasing evidence shows aberrant hypermethylation of genes occurring in and potentially
contributing to pathogenesis of myeloid malignancies. Several of these diseases, such as …

Patterns of DNA methylation are established during embryonic development and faithfully
copied through somatic cell divisions. Based on current understanding of DNA methylation …