The phenotype of the cancerous cell may arise either from genetic alterations that disrupt
gene function through sequence modifications (mutations) or epigenetic events that may …

Transcriptional silencing of tumor suppressor genes by DNA methylation occurs in cancer
cell lines and in human tumors. This has led to the pursuit of DNA methyltransferase …

Recent conceptual advances in the field of DNA methylation and the advent and rapid
development of new technologies in epigenomics have started to unravel the mechanisms …

Abnormalities of genomic methylation patterns have been attributed a role in carcinogenesis
since the early 1980s, when large-scale demethylation of the genome was thought be an …

The current management of breast cancer (BC) lacks specific non‑invasive biomarkers able
to provide an early diagnosis of the disease. Epigenetic‑sensitive signatures are influenced …

Aberrant DNA methylation is known as an important cause of human cancers, along with
mutations. Although aberrant methylation was initially speculated to be similar to mutations …

Hypermethylation of tumor suppressor genes caused by aberrant activity of DNA
methyltransferases is an important mechanism that contributes to cancer. The reaction …

There is compelling evidence to support the importance of DNA methylation alterations in
cancer development. Both losses and gains of DNA methylation are observed, thought to …

The mechanism of action of DNA methylation inhibitor 5-aza-2′-deoxycytidine (5-aza-
CdR), a potential anticancer agent is believed to be activated by the demethylation of tumor …

Publisher Summary This chapter discusses the role of DNA methylation in carcinogenesis
and tumor diversification. The methylation of HpaII and Hha1 sites in DNA isolated from the …