The prognosis of lung cancer is very much limited by the difficulties of diagnosing early
stage disease amenable to surgery. Thus, novel diagnostic and therapeutic approaches are …

Leukaemogenesis is a multi-step process whereby a clonal population arises that has
undergone successive alterations to the genotype and the phenotype of the cells that make …

Next year will mark 60 years since Dr. Leslie Foulds outlined his hypothesis that cancer is “a
dynamic process advancing through stages that are qualitatively different,” leading the way …

Epigenetic modifications include DNA methylation and covalent modification of histones.
These alterations are reversible but very stable and exert a significant impact on the …

Recently, the concept that epigenetic, as well as genetic, events might be central to the
evolution of human cancer is re-emerging. Cancers often exhibit an aberrant methylation of …

Aberrant DNA methylation of the promoter region is a key mechanism for inactivation of
genes that suppress tumorigenesis. Genes that are involved in every step of tumor formation …

Although chemotherapy is considered the mainstay of cancer therapy, unfortunate side
effects of chemotherapy create a continuous demand for developing other novel and specific …

DNA methylation is a mammalian epigenetic mark that is involved in defining where and
when genes are expressed, both in normal cells and in the context of diseases. Like other …

Tumorigenesis begins with the disregulated growth of an abnormal cell that has acquired
the ability to divide more rapidly than its normal counterparts (Nowell, PC (1976) Science …

The pharmacological inhibition of DNA methyltransferases provides novel opportunities for
the therapy of human cancers. Several Phase III trials of DNA methyltransferase inhibitors …