Clinical implications of aberrant DNA methylation patterns in acute myelogenous leukemia
O Galm, S Wilop, C Lüders, E Jost, G Gehbauer… - Annals of …, 2005 - Springer
Hypermethylation of CpG islands near gene promoter regions is associated with
transcriptional inactivation and represents an important mechanism of gene silencing in …
transcriptional inactivation and represents an important mechanism of gene silencing in …
The impact of DNA methylation in hematopoietic malignancies
Aberrant DNA methylation is a characteristic feature of cancers including blood
malignancies. Mutations in the DNA methylation regulators DNMT3A, TET1/2, and IDH1/2 …
malignancies. Mutations in the DNA methylation regulators DNMT3A, TET1/2, and IDH1/2 …
Epigenetic and chromatin modifiers as targeted therapy of hematologic malignancies
KN Bhalla - Journal of Clinical Oncology, 2005 - ascopubs.org
Epigenetic regulation of gene expression is mediated through alterations in the DNA
methylation status, covalent modifications of core nucleosomal histones, rearrangement of …
methylation status, covalent modifications of core nucleosomal histones, rearrangement of …
The DNA methylation machinery as a target for anticancer therapy
M Szyf - Pharmacology & therapeutics, 1996 - Elsevier
DNA methylation is now recognized as an important mechanism regulating different
functions of the genome; gene expression, replication, and cancer. Different factors control …
functions of the genome; gene expression, replication, and cancer. Different factors control …