A correlation between DNA methylation and transcriptional silencing has existed for many
years. Recently, substantial progress has been reported in the search for proteins that …

Since its discovery, methylation of DNA in mammalian cells has been correlated with
transcriptional repression and with specialized chromatin structures. Recently, considerable …

The methyl-CpG-binding protein 2 (MECP2) serves both organizational and transcriptional
functions in the nucleus, with two well-characterized domains integrally related to these …

A family of proteins conserved throughout the eukaryotic lineage is characterized by the
presence of a common sequence motif—the methyl-CpG-binding domain, or MBD. This …

Mutations of the methylated DNA binding protein MeCP2, a multifunctional protein that is
thought to transmit epigenetic information encoded as methylated CpG dinucleotides to the …

DNA methylation is interpreted by a family of methyl-CpG binding domain (MBD) proteins
that repress transcription through recruitment of corepressors that modify chromatin. To …

DNA promoter hypermethylation has been shown to be a functional mechanism of
transcriptional repression. This epigenetic gene silencing is thought to involve the …

Methylation of DNA in mammalian cells serves to demarcate functionally specialized regions
of the genome and is strongly associated with transcriptional repression. A highly conserved …

Since the discovery of its fundamental involvement in Rett syndrome, methyl CpG binding
protein 2 (MeCP2) has been the focus of an exhaustive biochemical and functional …

DNA methylation is an epigenetic modification that is implicated in transcriptional silencing.
It is becoming increasingly clear that both correct levels and proper interpretation of DNA …