DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-
based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future …

Biomarkers are naturally-occurring characteristics by which a particular pathological process
or disease can be identified or monitored. They can reflect past environmental exposures …

The past few years have seen an explosion of interest in the epigenetics of cancer. This has
been a consequence of both the exciting coalescence of the chromatin and DNA …

Epigenetics, transcending genetics, genomics, and molecular biology, is now poised to be
the avant-garde beacon of biological science. The rise of DNA methylation studies marks a …

DNA methylation at cytosines followed by guanines, CpGs, forms one of the multiple layers
of epigenetic mechanisms controlling and modulating gene expression through chromatin …

The spatial arrangement and three-dimensional structure of DNA in the nucleus is controlled
through the interdigitation of DNA binding proteins such as histones and their modifiers, the …

Epigenetic mechanisms are essential for normal development and maintenance of tissue-
specific gene expression patterns in mammals. Disruption of epigenetic processes can lead …

Recent conceptual advances in the field of DNA methylation and the advent and rapid
development of new technologies in epigenomics have started to unravel the mechanisms …

Deregulation of the epigenome is now recognized as a major mechanism involved in the
development and progression of human diseases such as cancer. As opposed to the …

A spate of high-powered genome-wide association studies (GWAS) have recently identified
numerous single-nucleotide polymorphisms (SNPs) robustly linked with complex disease …