The methylation of CpG islands is associated with transcriptional repression and, in cancer,
leads to the abnormal silencing of tumor suppressor genes. Because aberrant …

Hypermethylation in cancer often occurs in CpG islands that span the promoter regions of
tumor suppressor genes. However, it is not clear if hypermethylation is limited to single …

The genetic and epigenetic alterations that underlie cancer pathogenesis are rapidly being
identified. This provides novel insights in tumor biology as well as in potential cancer …

CpG island methylation is an epigenetic alteration that contributes to tumorigenesis by
transcriptional inactivation of genes. Little is known about the overall levels of CpG island …

We performed a genome-wide analysis of promoter associated CpG island methylation
using methylated CpG island amplification (MCA) coupled to representational differential …

Hypermethylation of CpG islands near gene promoter regions is associated with
transcriptional inactivation and represents an important mechanism of gene silencing in …

CpG island hypermethylation is known to be associated with gene silencing in cancer. This
epigenetic event is generally accepted as a stochastic process in tumor cells resulting from …

Background: Many cancers display alterations in methylation patterns of CpG islands—
stretches of DNA rich in CpG dinucleotides often associated with gene promoters that are …

Hypermethylation of CpG islands is a common epigenetic alteration associated with cancer.
Global patterns of hypermethylation are tumor-type specific and nonrandom. The biological …

Precise mapping of DNA methylation patterns in CpG islands has become essential for
understanding diverse biological processes such as the regulation of imprinted genes, X …