Epigenetics refers to heritable phenotypic alterations in the absence of DNA sequence
changes, and DNA methylation is one of the extensively studied epigenetic alterations. DNA …

Background Uncovering mechanisms of epigenome evolution is an essential step towards
understanding the evolution of different cellular phenotypes. While studies have confirmed …

DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

DNA methylation is a major epigenetic regulatory mechanism for gene expression and cell
differentiation. Until recently, it was still unclear how unmethylated regions in mammalian …

DNA methylation in mammals is a key epigenetic modification essential to normal genome
regulation and development. DNA methylation patterns are established during early …

Alterations in DNA methylation have been implicated in mammalian development. Hence,
the identification of tissue-specific differentially methylated regions (TDMs) is indispensable …

Parent-specific differentially methylated regions (DMRs) are established during
gametogenesis and regulate parent-specific expression of imprinted genes. Monoallelic …

In mammals, DNA methylation is a crucial epigenetic modification with key functions during
development. Cellular processes that are regulated by DNA methylation comprise X …

DNA methylation, the addition of a methyl group at the 5-position of cytosine (5-
methylcytosine, 5mC), is a major epigenetic modification in the genomes of many animals …

DNA methylation is one of the most important heritable epigenetic modifications of the
genome and is involved in the regulation of many cellular processes. Aberrant DNA …