The acquisition of iron and the maintenance of iron homeostasis are important aspects of
virulence for the pathogenic fungus Cryptococcus neoformans. In this study, we …

Monothiol glutaredoxins are important regulators of iron homeostasis that play conserved
roles in the sensing and trafficking of iron-sulfur clusters. We previously characterized the …

Iron acquisition is essential for the proliferation of microorganisms, and human pathogens
such as the fungus Cryptococcus neoformans must use sophisticated uptake mechanisms to …

Iron acquisition is critical for pathogenic fungi to adapt to and survive within the host
environment. However, to same extent, the fungi must also avoid the detrimental effects …

The level of available iron in the mammalian host is extremely low, and pathogenic microbes
must compete with host proteins such as transferrin for iron. Iron regulation of gene …

Vertebrate hosts actively sequester iron, and fungal and other pathogens must therefore
adapt to a severe limitation in iron availability to cause disease. Recent studies reveal that …

Iron is an essential nutrient required as a cofactor for many biological processes. As a fungal
commensal-pathogen of humans, Candida albicans encounters a range of bioavailable iron …

The fungal pathogen Cryptococcus neoformans is a major cause of illness in
immunocompromised individuals such as AIDS patients. The ability of the fungus to acquire …

Iron acquisition is a critical aspect of the virulence of many pathogenic microbes, and iron
limitation is an important defense mechanism for mammalian hosts. We are examining …

Iron plays a key role in host-pathogen interactions. Microbial pathogens require iron for
survival and virulence, whereas mammalian hosts sequester and withhold iron as a means …