Infants undergo extensive developments during their first year of life. Although the biological
mechanisms involved are not yet fully understood, changes in the DNA methylation in …

Background Preterm birth associates with a substantially increased risk of later
cardiovascular disease and neurodevelopmental disorders. Understanding underlying …

The placenta acts not only as a conduit of nutrient and waste exchange between mother and
developing fetus, but also functions as a regulator of the intrauterine environment. Recent …

Traditionally, DNA methylation has been thought of as being involved in gene silencing, but
work in recent years has shown a more complex picture, and the relationship between DNA …

Background Changes in DNA methylation in the mammalian genome during development
are frequent events and play major roles regulating gene expression and other …

Low birthweight and reduced height gain during infancy (stunting) may arise at least in part
from adverse early life environments that trigger epigenetic reprogramming that may favor …

One of the most critical epigenetic signatures present in the genome of higher eukaryotes is
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …

An increasing number of population studies are assessing epigenetic variation in relation to
early-life outcomes in tissues accessible to epidemiologic researchers. Epigenetic …

Throughout in utero development, the placenta plays a key role in controlling growth and
development. The placenta acts not only as a gatekeeper of nutrient and waste exchange …

Background Preterm birth confers a high risk of adverse long term health outcomes for
survivors, yet the underlying molecular mechanisms are unclear. We hypothesized that …