GC-MS determination of ratios of stable-isotope labelled to natural urea using [13C15N2] urea for studying urea kinetics in serum and as a means to validate routine …

BG Wolthers, T Tepper, A Withag, GT Nagel… - Clinica chimica acta, 1994 - Elsevier
Abstract A GC-MS determination of urea in serum or spent dialysate is described, using 13 C
15 N 2-labelled urea and assaying the area ratio of labelled to natural urea by mass …

Assay of stable isotope labelled urea in biological fluids by selected ion monitoring

JE Nelson, TI Ruo - Clinica chimica acta, 1988 - Elsevier
A selected ion-monitoring method, incorporating an internal standard, was developed to
allow the direct and simultaneous measurement of stable isotopelabelled urea and …

Determination of serum urea by isotope dilution mass spectrometry as a candidate definitive method

MJ Welch, A Cohen, HS Hertz, FC Ruegg… - Analytical …, 1984 - ACS Publications
An Isotope dilution mass spectrometrlc (ID/MS) method for serum urea Is described. The
method utilizes urea-180 as the labeled Internal standard and Involves Isolation of urea from …

Gas chromatography/mass spectrometric determination of [15N] urea in plasma and application to urea metabolism study

KY Tserng, SC Kalhan - Analytical Chemistry, 1982 - ACS Publications
The study of urea metabolism In humans necessitates sen-sitive methods, so that very low
Isotopic enrichments of plasma or urinary urea can be measured. A stable derivative of urea …

Determination of Serum Urea by Isotope Dilution Method Using Discharge-Assisted Thermospray Liquid Chromatotraghy/Mass Spectrometry

A Takatsu, S Nishi - Analytical sciences, 1995 - jstage.jst.go.jp
Measurements of serum urea concentration in monitoring of renal functions or of protein
metabolism have been performed routinely in clinical laboratories. Recent recognition of the …

Measurement of urea in human serum by isotope dilution mass spectrometry: a reference procedure

A Kessler, L Siekmann - Clinical Chemistry, 1999 - academic.oup.com
Background: A reference measurement procedure is needed to demonstrate the traceability
of results of urea measurements in human serum. We developed a measurement procedure …

Improvements in the determination of urea using diacetyl monoxime; methods with and without deproteinisation

M Rahmatullah, TRC Boyde - Clinica chimica acta, 1980 - Elsevier
A rapid and reproducible method is described for measurement of urea in biological
materials (after deproteinisation) and in serum (without deproteinisation). Urea is …

Liquid-chromatographic profiling of solutes in serum of uremic patients undergoing hemodialysis and chronic ambulatory peritoneal dialysis (CAPD); high …

AC Schoots, PG Gerlag, AW Mulder… - Clinical …, 1988 - academic.oup.com
Using" high performance" liquid chromatography, we studied non-protein-bound fractions
and total concentrations of 18 solutes accumulating in sera from a group of 12 patients who …

Simple and rapid quantitative assay of 13C-labelled urea in human serum using liquid chromatography—atmospheric pressure chemical ionization mass …

T Tanigawa, Y Mizo-oku, K Moriguchi, T Suzuki… - … of Chromatography B …, 1996 - Elsevier
A simple and rapid quantitative method for 13C-labelled urea ([13C] urea) in human serum
was developed by using high-performance liquid chromatography-atmospheric pressure …

Determination of uric acid in human serum by isotope dilution-mass spectrometry. Definitive methods in clinical chemistry, III

L Siekmann - 1985 - degruyter.com
A method for the measurement of uric acid in human serum by isotope dilution-mass
spectrometry is described. The analytical procedure consists of the following Steps:(1) …